[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

Base Information

Chemical Name:[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester
CAS No.:366490-49-5
Molecular Formula:C₂₈H₂₈N₄O₈P₂
Molecular Weight:610.5
Hs Code.:

Synonyms:[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

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Chemical Property of [3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

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Technology Process of [3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

There total 5 articles about [3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 366490-48-4
[3-({4'-[3-(dimethoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid dimethyl ester

: 366490-49-5
[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

Guidance literature:: With 4-methyl-morpholine; In methanol; N,N-dimethyl acetamide; at 70 ℃; for 168h;
DOI:10.1021/ja010931q

Reference yield:

: 72460-28-7
2,2'-bipyridyl-4,4'-dicarboxylic acid chloride

: 366490-49-5
[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Et₃N / N,N-dimethyl-acetamide / 12 h / 20 °C

2: 98 percent / N-methylmorpholine / N,N-dimethyl-acetamide; methanol / 168 h / 70 °C

With 4-methyl-morpholine; triethylamine; In methanol; N,N-dimethyl acetamide;
DOI:10.1021/ja010931q

Reference yield:

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 366490-49-5
[3-({4'-[3-(hydroxy-methoxy-phosphorylmethyl)-phenylcarbamoyl]-[2,2']bipyridinyl-4-carbonyl}-amino)-benzyl]-phosphonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2 h / 100 °C

2: NaBH₄; NiCl₂

3: 65 percent / Et₃N / N,N-dimethyl-acetamide / 12 h / 20 °C

4: 98 percent / N-methylmorpholine / N,N-dimethyl-acetamide; methanol / 168 h / 70 °C

With 4-methyl-morpholine; sodium tetrahydroborate; triethylamine; nickel dichloride; In methanol; N,N-dimethyl acetamide;
DOI:10.1021/ja010931q