(R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Base Information

• Chemical Name: (R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
• CAS No.: 1616074-39-5
• Molecular Formula: C₂₈H₃₉FN₂O₄
• Molecular Weight: 485.629

Synonyms:(R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Chemical Property of (R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of (R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile

There total 2 articles about (R)-5-((3,4-dimethoxyphenethyl)(2-[¹⁸F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-Norverapamil (67018-85-3) + 1-bromo-2-[18F]fluoroethane (85725-77-5) → (R)-5-((3,4-dimethoxyphenethyl)(2-[18F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile (1616074-39-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.25h;

Reference yield:

(+)-Norverapamil (67018-85-3) + 2-[18F]fluoroethyl triflate (124840-53-5) → (R)-5-((3,4-dimethoxyphenethyl)(2-[18F]fluoroethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile (1616074-39-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 0 - 120 ℃; for 0.25h;

DOI:10.1021/acschemneuro.7b00086

upstream raw materials:

(+)-Norverapamil

1-bromo-2-[¹⁸F]fluoroethane

2-[¹⁸F]fluoroethyl triflate

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