Norverapamil

Base Information

Chemical Name:Norverapamil
CAS No.:67018-85-3
Molecular Formula:C26H36 N2 O4
Molecular Weight:440.583
Hs Code.:
European Community (EC) Number:266-544-8
NSC Number:672815
UNII:957Z3K3R56
DSSTox Substance ID:DTXSID80873799
Nikkaji Number:J264.593I
Wikipedia:Norverapamil
Wikidata:Q7060761
Pharos Ligand ID:3QHWMCH6W2RX
Metabolomics Workbench ID:123276
ChEMBL ID:CHEMBL1298
Mol file:67018-85-3.mol

Synonyms:D 591;N-demethylverapamil;norverapamil;norverapamil monohydrochloride;norverapamil, (+-)-isomer

Suppliers and Price of Norverapamil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
NORVERAPAMIL 95.00%
1MG
$ 636.70

Total 29 raw suppliers

Chemical Property of Norverapamil

Chemical Property:

Vapor Pressure:1.02E-13mmHg at 25°C
Boiling Point:586.1°C at 760 mmHg
PKA:9.79±0.19(Predicted)
Flash Point:308.2°C
PSA：72.74000
Density:1.063±0.06 g/cm3(Predicted)
LogP:5.94378
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:440.26750763
Heavy Atom Count:32
Complexity:577

Purity/Quality:

98%Min ^*data from raw suppliers

NORVERAPAMIL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(CCCNCCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC

Technology Process of Norverapamil

There total 17 articles about Norverapamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 27487-83-8
2-(3,4-dimethoxyphenyl)-2-isopropyl-2-(3-chloropropyl)acetonitrile

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 67018-85-3,73980-36-6,123931-31-7,123932-43-4
norverapamil

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;
DOI:10.1016/j.bmcl.2014.05.022

Reference yield:

: 52-53-9,56949-77-0
Verapamil

: 27487-66-7
D 620

: 34245-14-2
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino-pentanenitrile

: 67018-85-3,73980-36-6,123931-31-7,123932-43-4
norverapamil

Guidance literature:: With NADPH; In water; dimethyl sulfoxide; at 37 ℃; for 1h; Microbiological reaction;
DOI:10.1002/rcm.4465

Reference yield:

: 52-53-9,56949-77-0
Verapamil

: 34245-14-2
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino-pentanenitrile

: 67018-85-3,73980-36-6,123931-31-7,123932-43-4
norverapamil

: D 702

Guidance literature:: With cytochrome P₄₅₀ BM₃ chimera variant 11113311; at 37 ℃; for 1h; aq. phosphate buffer; Enzymatic reaction;
DOI:10.1002/chem.200900643