phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:180335-86-8
Molecular Formula:C₅₇H₇₇N₄O₁₃P
Molecular Weight:1057.23
Hs Code.:

phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Synonyms:phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 9 articles about phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3416-05-5
3'-Deoxythymidine

: 3'-O-(4,4'-dimethoxytrityl)thymidine 5'-(hexadecyl phosphate), sodium salt

: 180335-86-8
phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; at 20 - 45 ℃; for 2h;
DOI:10.1016/0008-6215(96)00042-0

Reference yield:

: 36653-82-4,124-29-8
1-Hexadecanol

: 180335-86-8
phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / PCl₃ / acetonitrile / 0.58 h / 20 °C

2: sym-collidine / tetrahydrofuran / 0.5 h / -78 °C

3: NaHCO₃; water / tetrahydrofuran

4: I₂; water / tetrahydrofuran; pyridine / 0.25 h

5: 84 percent / 2,4,6-tri-isopropylbenzenesulfonyl chloride; 1-methylimidazole / pyridine / 2 h / 20 - 45 °C

With 1-methyl-1H-imidazole; 2,4,6-trimethyl-pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; water; iodine; sodium hydrogencarbonate; phosphorus trichloride; In tetrahydrofuran; pyridine; acetonitrile; 1: phosphorodichloriditation / 2: phosphitylation / 3: Hydrolysis / 4: Oxidation / 5: Esterification;
DOI:10.1016/0008-6215(96)00042-0

Reference yield:

: 76054-81-4
3'-O-(4,4'-dimethoxytrityl)thymidine

: 180335-86-8
phosphoric acid 3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester hexadecyl ester 5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sym-collidine / tetrahydrofuran / 0.5 h / -78 °C

2: NaHCO₃; water / tetrahydrofuran

3: I₂; water / tetrahydrofuran; pyridine / 0.25 h

4: 84 percent / 2,4,6-tri-isopropylbenzenesulfonyl chloride; 1-methylimidazole / pyridine / 2 h / 20 - 45 °C

With 1-methyl-1H-imidazole; 2,4,6-trimethyl-pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; water; iodine; sodium hydrogencarbonate; In tetrahydrofuran; pyridine; 1: phosphitylation / 2: Hydrolysis / 3: Oxidation / 4: Esterification;
DOI:10.1016/0008-6215(96)00042-0