9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

Base Information

Chemical Name:9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether
CAS No.:133447-42-4
Molecular Formula:C₄₀H₆₂O₃Si
Molecular Weight:619.016
Hs Code.:

Synonyms:9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

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Chemical Property of 9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

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Technology Process of 9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

There total 5 articles about 9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-97-0
vitamin D₃

: 133447-42-4
9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 5 steps

1: 1) pyridine, ozone, 2)NaBH₄ / methanol, 1) -78 deg C, 2h, 2a) 3* -78 deg C, 20 min 2b) -78 deg C -> r.t., overnight, 2c) 1h, r.t.

2: 84 percent / pyridinium dichromate, pyridinium p-toluensulfonate / CH₂Cl₂ / 15 h / Ambient temperature

3: 1) lithium diisopropylamide, 2) MoOPH / THF, hexane, 1) -78 deg C, 30 min, 2) -60 deg C, 4 h

4: 91 percent / pyridine / DMPA / 1) 0 deg C, 3 h, 2) r.t., overnight

5: 1) MeLi-LiBr / 1) THF, hexane, -90 deg C, 30 min, 2) THF, -90 deg C, 3 h

With pyridine; sodium tetrahydroborate; dipyridinium dichromate; MoO₅*pyridine*HMPA; methyllithium; pyridinium p-toluenesulfonate; ozone; lithium bromide; lithium diisopropyl amide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In dichloromethane;
DOI:10.1021/jo00011a024

Reference yield:

: 33813-99-9
Grundmann's alcohol

: 133447-42-4
9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / pyridinium dichromate, pyridinium p-toluensulfonate / CH₂Cl₂ / 15 h / Ambient temperature

2: 1) lithium diisopropylamide, 2) MoOPH / THF, hexane, 1) -78 deg C, 30 min, 2) -60 deg C, 4 h

3: 91 percent / pyridine / DMPA / 1) 0 deg C, 3 h, 2) r.t., overnight

4: 1) MeLi-LiBr / 1) THF, hexane, -90 deg C, 30 min, 2) THF, -90 deg C, 3 h

With pyridine; dipyridinium dichromate; MoO₅*pyridine*HMPA; methyllithium; pyridinium p-toluenesulfonate; lithium bromide; lithium diisopropyl amide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In dichloromethane;
DOI:10.1021/jo00011a024

Reference yield:

: 66251-18-1
Grundmann's ketone

: 133447-42-4
9α-(benzoyloxy)-(7E)-vitamin D3 tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 1) lithium diisopropylamide, 2) MoOPH / THF, hexane, 1) -78 deg C, 30 min, 2) -60 deg C, 4 h

2: 91 percent / pyridine / DMPA / 1) 0 deg C, 3 h, 2) r.t., overnight

3: 1) MeLi-LiBr / 1) THF, hexane, -90 deg C, 30 min, 2) THF, -90 deg C, 3 h

With pyridine; MoO₅*pyridine*HMPA; methyllithium; lithium bromide; lithium diisopropyl amide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate;
DOI:10.1021/jo00011a024