methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

Base Information

Chemical Name:methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate
CAS No.:1380324-11-7
Molecular Formula:C₂₁H₁₇ClF₂N₂O₄
Molecular Weight:434.827
Hs Code.:

Synonyms:methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

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Chemical Property of methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

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Technology Process of methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

There total 5 articles about methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380324-10-6
methyl 4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-1,4'-bipyridine-2'-carboxylate

: 1380324-11-7
methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

Guidance literature:: With dichloro-acetic acid; N-chloro-succinimide; In isopropyl alcohol; at 60 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1380324-08-2
2'-chloro-4-hydroxy-5',6-dimethyl-2H-[1,4'-bipyridin]-2-one

: 1380324-11-7
methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: triethylamine / BINAP-PdCl₂ / 16 h / 100 °C / 1551.49 Torr / Autoclave; Inert atmosphere

3: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 2 h / 60 °C / Inert atmosphere

With dichloro-acetic acid; N-chloro-succinimide; potassium carbonate; triethylamine; BINAP-PdCl₂; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 79055-62-2
2-chloro-5-methyl-pyridin-4-ylamine

: 1380324-11-7
methyl 3-chloro-4-[(2,4-difluorobenzyl)oxy]-5',6-dimethyl-2-oxo-2H-[1,4'-bipyridine]-2'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride / 0.33 h / 160 °C / Sealed tube

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

3: triethylamine / BINAP-PdCl₂ / 16 h / 100 °C / 1551.49 Torr / Autoclave; Inert atmosphere

4: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 2 h / 60 °C / Inert atmosphere

With dichloro-acetic acid; N-chloro-succinimide; potassium carbonate; triethylamine; lithium chloride; BINAP-PdCl₂; In N,N-dimethyl-formamide; isopropyl alcohol;