79055-62-2Relevant academic research and scientific papers
Selective sodium channel regulator, preparation and application thereof
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Paragraph 0188; 0189; 0190; 0191; 0192, (2021/07/01)
The invention provides a compound as a selective sodium channel regulator, a synthesis method and a use method thereof, and particularly provides a compound as shown in a formula (I), a preparation method of the compound and application of the compound as the selective sodium channel regulator. The compounds exhibit excellent activity as sodium channel modulators.
PRMT5 INHIBITORS
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Page/Page column 43; 47, (2019/05/30)
The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.
2-hydroxy-4-amino-5-picoline heterocyclic compounds
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Paragraph 0025; 0035-0039, (2017/01/23)
The invention discloses a 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound which can be used as an intermediate for synthesizing an omeprazole compound. The invention further discloses a synthesis method of a 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound. The synthesis method comprises four steps of synthesis of 2-chloro-5-methylpyridine nitrogen oxide, synthesis of 2-chloro-4-nitro-5-methylpyridine nitrogen oxide, synthesis of 2-chloro-4-amino-5-methylpyridine and synthesis of 2-hydroxy-4-amino-5-methylpyridine. The synthesis method of the 2-hydroxy-4-amino-5-methylpyridine heterocyclic compound disclosed by the invention is simple, reaction raw materials are low in price, and a synthesis route is environment-friendly.
PYRIDINE INHIBITORS OF ERK2 AND USES THEREOF
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Page/Page column 24; 39, (2008/06/13)
The present invention relates to compounds useful of inhibitors of protein kinases of formula (I). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of var
PYRROLE DERIVATIVES AS INHIBITORS OF ERK2 AND USES THEREOF
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Page/Page column 49, (2010/02/07)
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 Are as described in t
