2-Hydroxy-4-methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Hydroxy-4-methyl-3-nitropyridine
• CAS No.: 21901-18-8
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.125
• Hs Code.: 29337900
• Mol file: 21901-18-8.mol

Synonyms:2-Pyridinol,4-methyl-3-nitro- (8CI);4-Methyl-3-nitro-2-pyridone;NSC 402986;

Chemical Property of 2-Hydroxy-4-methyl-3-nitropyridine

Chemical Property:

• Appearance/Colour: yellow crystalline powder
• Vapor Pressure: 0.000639mmHg at 25°C
• Melting Point: 229-232 °C(lit.)
• Refractive Index: 1.608
• Boiling Point: 352.5 °C at 760 mmHg
• PKA: 8.40±0.10(Predicted)
• Flash Point: 167 °C
• PSA: 78.94000
• Density: 1.36 g/cm³
• LogP: 1.52700
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxy-4-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Hydroxy-4-methyl-3-nitropyridine is a useful research chemical.

Technology Process of 2-Hydroxy-4-methyl-3-nitropyridine

There total 8 articles about 2-Hydroxy-4-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

2-amino-4-methyl-3-nitropyridine (6635-86-5,67476-70-4) → 2-hydroxy-4-methyl-3-nitropyridine (21901-18-8)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 0 ℃; Reflux;

Reference yield: 91.6%

2-amino-4-methyl-3-nitropyridine (6635-86-5,67476-70-4) → 4-Methyl-3-nitro-2-pyridone (21901-18-8)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 20 ℃; for 2h;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 2-hydroxy-4-methyl-5-nitropyridine (21901-41-7) + 2-hydroxy-4-methyl-3-nitropyridine (21901-18-8)

Guidance literature:

2-Amino-4-methylpyridine; With sulfuric acid; nitric acid;

With hydrogenchloride; sodium nitrite;

DOI:10.1016/j.jfluchem.2011.05.028

upstream raw materials:

2-amino-4-methyl-3-nitropyridine

2-Amino-4-methylpyridine

Downstream raw materials:

2-chloro-3-nitro-4-methylpyridine

3-amino-2-hydroxy-4-methylpyridine

3-benzoylamino-4-methyl-2-pyridone

2-chloro-3-nitroisonicotinic acid

Refernces

• 1、 Burton et al.. "-". . p. 2211. Retrieved 1971.
• 2、 Giannouli, Vassiliki,Gioti, Katerina,Horne, David A.,Kostakis, Ioannis K.,Lougiakis, Nikolaos,Mara-Kos, Panagiotis,Nam, Sangkil,Pouli, Nicole,Skaltsounis, Alexios-Leandros,Tenta, Roxane. "Design and synthesis of new substituted pyrazolopyridines with potent antiproliferative activity". . p. 176 - 191. Retrieved 2020/03/10.
• 3、 Sklepari, Meropi,Lougiakis, Nikolaos,Papastathopoulos, Athanasios,Pouli, Nicole,Marakos, Panagiotis,Myrianthopoulos, Vassilios,Robert, Thomas,Bach, Stéphane,Mikros, Emmanuel,Ruchaud, Sandrine. "Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines". . p. 66 - 81. Retrieved 2017/01/06.