Technology Process of N-(2-ethyl-4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine
There total 10 articles about N-(2-ethyl-4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 2 h / 20 °C
2.1: iron; acetic acid / 1 h / 50 - 80 °C
3.1: 4 h / 100 °C
4.1: tris-(dibenzylideneacetone)dipalladium(0); XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C
5.2: 0.5 h / 0 - 20 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 45004.5 Torr
7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
8.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; iron; acetic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 18 h / Reflux
2.1: tris-(dibenzylideneacetone)dipalladium(0); XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C
3.2: 0.5 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 60 °C / 45004.5 Torr
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; caesium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
