2-phenyl-N-((pyridin-3-yl)methyl)acetamide

Base Information

• Chemical Name: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide
• CAS No.: 349404-17-7
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.278
• Mol file: 349404-17-7.mol

Synonyms:2-phenyl-N-((pyridin-3-yl)methyl)acetamide

Chemical Property of 2-phenyl-N-((pyridin-3-yl)methyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-phenyl-N-((pyridin-3-yl)methyl)acetamide

There total 4 articles about 2-phenyl-N-((pyridin-3-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-Aminomethylpyridine (3731-52-0) + phenylacetic acid (103-82-2) → 2-phenyl-N-((pyridin-3-yl)methyl)acetamide (349404-17-7)

Guidance literature:

With Cp₂Zr(OTf)_2?THF; In tetrahydrofuran; at 70 ℃; for 48h; Sealed tube; Inert atmosphere;

DOI:10.1002/aoc.5062

Reference yield: 89.0%

3-Aminomethylpyridine (3731-52-0) + 4-Methoxyphenylacetic acid (104-01-8) → 2-phenyl-N-((pyridin-3-yl)methyl)acetamide (349404-17-7)

Guidance literature:

With (2-(thiophen-2-ylmethyl)phenyl)boronic acid; In dichloromethane; at 45 ℃; for 48h; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.joc.5b00378

Reference yield: 79.0%

3-Aminomethylpyridine (3731-52-0) + phenylacetic acid (103-82-2) → 2-phenyl-N-((pyridin-3-yl)methyl)acetamide (349404-17-7)

Guidance literature:

phenylacetic acid; solid phase supported [2-iodo-5-[3-(3-phenylpropanoylamino)propoxy]phenyl]boronic acid; In dichloromethane; at 25 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

3-Aminomethylpyridine; In dichloromethane; at 25 ℃; for 96h; Molecular sieve; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.06.043

upstream raw materials:

3-Aminomethylpyridine

phenylacetic acid

2-phenylethanol

4-Methoxyphenylacetic acid

Refernces

• 1、 -. "Method for preparing amide compounds through ionic liquid catalysis in high-pressure environment". Paragraph 0071-0074. . Retrieved 2021/01/24.
• 2、 Kim, Kunsoon,Kang, Byungjoon,Hong, Soon Hyeok. "N-Heterocyclic carbene-based well-defined ruthenium hydride complexes for direct amide synthesis from alcohols and amines under base-free conditions". . p. 4565 - 4569. Retrieved 2015/06/08.