3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

Base Information

Chemical Name:3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate
CAS No.:1621684-23-8
Molecular Formula:C₂₁H₂₁F₂N₅O₅
Molecular Weight:461.425
Hs Code.:

Synonyms:3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

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Chemical Property of 3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

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Technology Process of 3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

There total 3 articles about 3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1668599-81-2
[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propan-1-ol

: 23156-27-6
2,6-difluoro-4-nitroaniline

: 1621684-23-8
3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

Guidance literature:: bis(trichloromethyl) carbonate; 2,6-difluoro-4-nitroaniline; In dichloromethane; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propan-1-ol; In tetrahydrofuran; dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 1621684-23-8
3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 90 °C

3.1: dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

3.3: 12 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1621684-23-8
3-[4-(1,3-benzoxazol-2-yl)piperazin-1-yl]propyl-N-(2,6-difluoro-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / methanol / 48 h / 80 °C

2.1: dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

2.3: 12 h / 20 °C / Inert atmosphere

With ammonia; In methanol; dichloromethane;