di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

Base Information

Chemical Name:di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate
CAS No.:364343-82-8
Molecular Formula:C₁₇H₂₄N₂O₅
Molecular Weight:336.388
Hs Code.:

Synonyms:di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

Chemical Property:

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Technology Process of di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

There total 8 articles about di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4248-19-5
tert-butyl carbazate

: tert-butyl (3-bromo-4-formylphenyl)carbamate

: 364343-82-8
di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

Guidance literature:: With palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); caesium carbonate; In 1,4-dioxane; at 100 ℃; for 18h; Sealed tube;
DOI:10.1002/anie.202002391

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 364343-82-8
di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 18 h / 20 °C

3: caesium carbonate; palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO) / 1,4-dioxane / 18 h / 100 °C / Sealed tube

With palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); caesium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1002/anie.202002391

Reference yield:

: 16426-64-5
2-bromo-4-nitrobenzoic acid

: 364343-82-8
di-tert-butyl (4-formyl-1,3-phenylene)dicarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 18 h / 65 °C

2: tin(II) chloride dihdyrate / ethanol; ethyl acetate / 4 h / 85 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / 20 °C

5: Dess-Martin periodane / dichloromethane / 18 h / 20 °C

6: caesium carbonate; palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO) / 1,4-dioxane / 18 h / 100 °C / Sealed tube

With lithium aluminium tetrahydride; thionyl chloride; tin(II) chloride dihdyrate; palladium [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphine-κP](methanesulfonato-κO); caesium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;
DOI:10.1002/anie.202002391