[6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: [6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester
• CAS No.: 862536-36-5
• Molecular Formula: C₂₅H₂₈ClN₅O₄
• Molecular Weight: 497.981
• Mol file: 862536-36-5.mol

Synonyms:[6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester

Chemical Property of [6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester

There total 1 articles about [6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-{6-[tert-butoxycarbonyl-(2-chloro-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester + tert-butyl alcohol (75-65-0) → 5-[6-(2-chloro-phenylamino)-pyrazin-2-yl]-nicotinic acid + [6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester (862536-36-5)

Guidance literature:

5-{6-[tert-butoxycarbonyl-(2-chloro-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester; With sodium hydroxide; In methanol; at 0 - 20 ℃; for 18.3h;

tert-butyl alcohol; With diphenylphosphoranyl azide; triethylamine; In toluene; at 70 - 100 ℃; for 4.5h; Title compound not separated from byproducts;

DOI:10.1021/jm058205b

Reference yield:

[6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester (862536-36-5) + 3-(tert-butyldimethylsilyloxy)propyl bromide (89031-84-5) → [6-(5-{tert-butoxycarbonyl-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-amino}-pyridin-3-yl)-pyrazin-2-yl]-(2-chloro-phenyl)-carbamic acid tert-butyl ester

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 36h;

DOI:10.1021/jm058205b

Reference yield:

[6-(5-tert-butoxycarbonylaminopyridin-3-yl)pyrazin-2-yl]-(2-chlorophenyl)carbamic acid tert-butyl ester (862536-36-5) → 3-{5-[6-(2-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-propan-1-ol

Guidance literature:

Multi-step reaction with 2 steps

1: Cs₂CO₃ / dimethylformamide / 36 h / 70 °C

2: trifluoroacetic acid / 1 h / 20 °C

With caesium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm058205b

upstream raw materials:

tert-butyl alcohol