Technology Process of (R)-1-((4S,5S)-5-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-ol
There total 6 articles about (R)-1-((4S,5S)-5-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pentan-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
regioselective reaction;
DOI:10.1055/s-0033-1340348
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane
2.1: dichloromethane
3.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / 0 °C
4.1: hydrogen; triethylamine; 10 wt% Pd(OH)2 on carbon / benzene / 20 °C
5.1: lithium chloride; sodium persulfate; sodium tetrahydroborate; copper(II) trifluoroacetate hydrate name...; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate / acetonitrile / 0.25 h / 0 °C
5.2: 0.5 h / 20 °C
6.1: copper(l) iodide / tetrahydrofuran / 1 h / 0 °C
With
sodium tetrahydroborate; sodium persulfate; copper(l) iodide; tetrapropylammonium perruthennate; 10 wt% Pd(OH)2 on carbon; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; copper(II) trifluoroacetate hydrate name...; lithium chloride;
In
tetrahydrofuran; dichloromethane; acetonitrile; benzene;
2.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340348
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane
2.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / 0 °C
3.1: hydrogen; triethylamine; 10 wt% Pd(OH)2 on carbon / benzene / 20 °C
4.1: lithium chloride; sodium persulfate; sodium tetrahydroborate; copper(II) trifluoroacetate hydrate name...; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate / acetonitrile / 0.25 h / 0 °C
4.2: 0.5 h / 20 °C
5.1: copper(l) iodide / tetrahydrofuran / 1 h / 0 °C
With
sodium tetrahydroborate; sodium persulfate; copper(l) iodide; 10 wt% Pd(OH)2 on carbon; (2S,5R)‐2‐(tert‐butyl)‐3,5‐dimethylimidazolidin‐4‐one trifluoroacetate; hydrogen; diisobutylaluminium hydride; triethylamine; copper(II) trifluoroacetate hydrate name...; lithium chloride;
In
tetrahydrofuran; dichloromethane; acetonitrile; benzene;
1.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340348
