3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

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Chemical Name:3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid
CAS No.:1132941-08-2
Molecular Formula:C₁₆H₁₈N₂O₅
Molecular Weight:318.329
Hs Code.:

Synonyms:3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

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Chemical Property of 3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

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Technology Process of 3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

There total 5 articles about 3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1132941-06-0
methyl 3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate

: 1132941-08-2
3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

Guidance literature:: methyl 3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxybenzoate; With sodium hydroxide; ethanol; water; at 20 ℃; for 18h;

With hydrogenchloride; water; In ethanol;

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132941-08-2
3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; acetic acid / 2.5 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: iron; ammonium chloride / methanol; water / 1 h / Reflux

4.1: N,N-dimethyl acetamide; benzene / 4 h / -25 - 20 °C

4.2: 3 h / 100 °C

5.1: sodium hydroxide / water; ethanol / 18 h / 20 °C

With nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In methanol; ethanol; N,N-dimethyl acetamide; water; acetone; benzene;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 1132941-02-6
methyl 5-amino-3-tert-butyl-2-methoxybenzoate

: 1132941-08-2
3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl acetamide; benzene / 4 h / -25 - 20 °C

1.2: 3 h / 100 °C

2.1: sodium hydroxide / water; ethanol / 18 h / 20 °C

With sodium hydroxide; In ethanol; N,N-dimethyl acetamide; water; benzene;
DOI:10.1021/acs.jmedchem.7b01630