15018-03-8

Usage

InChI:InChI=1/C16H24O3/c1-15(2,3)10-8-11(14(18)19-7)13(17)12(9-10)16(4,5)6/h8-9,17H,1-7H3

Upstream product

• 75-65-0 tert-butyl alcohol 
• 119-36-8 methyl salicylate 
• 115-11-7 isobutene 
• 19715-19-6 3,5-ditertbutyl salicylic acid 
• 85622-93-1 temozolomide 

Downstream Products

• 19715-19-6 3,5-ditertbutyl salicylic acid 
• 372137-83-2 methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate 
• 175650-09-6 2-benzyloxy-3,5-di-tert-butylbenzoic acid 
• 175650-10-9 2-benzyloxy-3,5-di-tert-butylbenzoyl chloride 
• 853268-38-9 1,8-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)naphthalene 
• 853268-36-7 1,2-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)benzene 
• 853268-37-8 2,6-bis-(3,5-di-tert-butyl-2-benzyloxybenzamido)pyridine 
• 853268-41-4 1,8-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)naphthalene 
• 853268-39-0 1,2-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)benzene 
• 512802-96-9 1,2-bis-(3,5-di-tert-butyl-2-hydroxybenzamido)ethane 

Relevant academic research and scientific papers

A novel switch on and reversible optical sensor as an efficient, selective receptor for Zn(II) ion and its biological application

In the present study, a promising optical sensor (TR) was designed, synthesized, characterized and its chemosensing mechanism has been explored through 1H NMR, ESI-MS, UV–Vis absorption and emission spectral studies. This compound exhibits a dr

Convenient and efficient method for the obtainment of ketones from highly hindered aromatic N,N-dimethyl-amides

A simple and efficient procedure to synthesize highly hindered alkyl aryl ketones that involves the coupling of N,N-dimethyl-3,5-di-tert-butylsalicylamide with organolithium compounds is described. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the procedure. Copyright Taylor & Francis Group, LLC.

A highly selective and sensitive turn on optical probe as a promising molecular platform for rapid detection of Zn (II) ion in acetonitrile medium: Experimental and theoretical investigations

A highly Zn2+ ion responsive novel cation sensor (L) based on the dual mechanism (ESIPT/ICT) was designed, synthesized and characterized. The sensor L shows great turn on selectivity for Zn2+ ion in 1:1 stoichiometric manner via rapid color change and 5-fold fluorescence enhancement in CH3CN over other interfering cations. The addition of Zn2+ ion to L, triggers the deprotonation of imidolic and hydroxylic protons of L, which in turn shows an enhanced red shift in both UV–Vis and fluorescence spectra of the sensor. The limit of detection and binding constant obtained are well within those reported for Zn2+ ion. The theoretical calculations were correlated with experimental results to understand the sensing mechanism between host guest interactions and L distinguishes Zn2+ from Cd2+. Furthermore, bioimaging studies were undertaken to investigate practical usefulness of L to recognize Zn2+ ion using HeLa cells.

Structurally Modelling the 2-His-1-Carboxylate Facial Triad with a Bulky N,N,O Phenolate Ligand

We present the synthesis and coordination chemistry of a bulky, tripodal N,N,O ligand, ImPh2NNOtBu (L), designed to model the 2-His-1-carboxylate facial triad (2H1C) by means of two imidazole groups and an anionic 2,4-di-tert-butyl-s

An ESIPT blocked highly ICT based molecular probe to sense Zn (II) ion through turn on optical response: Experimental and theoretical studies

A simple and low cost optical sensor (L) is synthesized by the condensation reaction and characterized systematically. Among the various tested metal ions, L selectively interacts with Zn2+ ion by inducing a 17-fold high fluorescence intensity

Selective and sensitive optical probe for the recognition of Zn (II) ion through turn-on optical response in aqueous medium: Experimental and theoretical approach

A selective and sensitive Zn(II) ion responsive optical probe (E)-N′-(2, 4-dihydroxybenzylidene)-3, 5-di-tert-butyl-2-hydroxybenzohydrazide (L) was designed, synthesized and characterized. The optical behavior of L towards different metal ions were invest

Synthesis method of 5-tert-butyl-2-methyl hydroxybenzoate

The invention discloses a synthesis method of methyl 5-tert-butyl-2-hydroxybenzoate, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps of: S1,taking methyl salicylate and tert-butyl alcohol as raw materials, and preparing a mixture of a compound shown as a formula (I), a compound shown as a formula (II) and a compound shown as a formula (III) under the catalytic action of concentrated sulfuric acid; and S2, carrying out a rearrangement reaction on the mixture prepared in the step S1 under the catalysis of Lewis acid, and carrying out post-treatment to prepare a pure compound shown in the formula (I), namely the 5-tert-butyl-2-methyl hydroxybenzoate. The synthesis method of the 5-tert-butyl-2-methyl hydroxybenzoate is low in production cost, novel in preparation route, simple in equipment and easy for industrial production, and can be widely applied to the field of production of fine chemicals.

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations

Diazomethane is one of the most versatile reagents in organic synthesis, but its utility is limited by its hazardous nature. Although alternative methods exist to perform the unique chemistry of diazomethane, these suffer from diminished reactivity and/or correspondingly harsher conditions. Herein, we describe the repurposing of imidazotetrazines (such as temozolomide, TMZ, the standard of care for glioblastoma) for use as synthetic precursors of alkyl diazonium reagents. TMZ was employed to conduct esterifications and metal-catalyzed cyclopropanations, and results show that methyl ester formation from a wide variety of substrates is especially efficient and operationally simple. TMZ is a commercially available solid that is non-explosive and non-toxic, and should find broad utility as a replacement for diazomethane.

Metal complex-(3,5-di-tert-butyl salicylic acid) method for the preparation of

The invention provides a preparation method for metal complex-(3,5- di-tert-butyl salicylic acid). The preparation method comprises the steps of dissolving 3,5- di-tert-butyl salicylic acid in alkali metal hydroxide liquor, and synthesizing the metal complex-(3,5- di-tert-butyl salicylic acid) by adopting different mixing ways with metal salt liquor at 60-70 DEG C, wherein the complex-(3,5- di-tert-butyl salicylic acid) can be used as an antistatic agent and a charge control agent for powdered ink. The invention further provides a method for preparing 3,5- di-tert-butyl salicylic acid by taking the methyl salicylate as the material through Friedel-Craft reaction and hydrolysis reaction of ester.

COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME

The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.