methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Base Information

Chemical Name:methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate
CAS No.:1584301-98-3
Molecular Formula:C₃₉H₄₅N₃O₇
Molecular Weight:667.802
Hs Code.:

Synonyms:methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

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Chemical Property of methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Chemical Property:

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Technology Process of methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

There total 7 articles about methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584301-67-6
5-(2,4-bis-(benzyloxy)-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylic acid

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 1584301-98-3
methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 1584301-90-5
ethyl 5-(2,4-bis(benzyloxy)-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylate

: 1584301-98-3
methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 1584301-98-3
methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / toluene / Reflux

2: triethylamine / dichloromethane

3: trifluoroacetic acid / dichloromethane / Reflux

4: hydrogenchloride / water / Reflux

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

6: lithium hydroxide monohydrate / water; tetrahydrofuran

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2014.01.056