methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Base Information

Chemical Name:methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate
CAS No.:1584301-75-6
Molecular Formula:C₂₅H₃₃N₃O₇
Molecular Weight:487.553
Hs Code.:

Synonyms:methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

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Chemical Property of methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

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Technology Process of methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

There total 9 articles about methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1584301-98-3
methyl 7-(5-(2,4-dibenzyloxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

: 1584301-75-6
methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 1584301-75-6
methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C

2: boron trichloride / dichloromethane / 0.5 h / -78 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 1584301-90-5
ethyl 5-(2,4-bis(benzyloxy)-5-isopropylbenzoyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylate

: 1584301-75-6
methyl 7-(5-(2,4-dihydroxy-5-isopropyl-benzoyl)-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3-carboxamido)-heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 4 h / 20 °C

3: boron trichloride / dichloromethane / 0.5 h / -78 °C

With lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.01.056