5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide

Base Information

• Chemical Name: 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide
• CAS No.: 475114-17-1
• Molecular Formula: C₁₈H₂₃N₅O₂S
• Molecular Weight: 373.479

Synonyms:5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide

Chemical Property of 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide

There total 4 articles about 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-hydrazono-ethyl)-phenyl]-amide (475114-13-7) → 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide (475114-17-1)

Guidance literature:

With manganese(IV) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2004.12.046

Reference yield:

5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (2-acetyl-phenyl)-amide (475114-09-1) → 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide (475114-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / hydrazine monohydrate / ethanol / 0.83 h / Heating

2: 130 mg / MnO₂ / dimethylformamide / 0.25 h / 20 °C

With manganese(IV) oxide; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.12.046

Reference yield:

2-aminoacetophenone (551-93-9) → 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-diazo-ethyl)-phenyl]-amide (475114-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.5 h

1.2: 72 percent / dimethylformamide / 3.5 h / 20 °C

2.1: 80 percent / hydrazine monohydrate / ethanol / 0.83 h / Heating

3.1: 130 mg / MnO₂ / dimethylformamide / 0.25 h / 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; hydrazine hydrate; isobutyl chloroformate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.12.046

upstream raw materials:

5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(1-hydrazono-ethyl)-phenyl]-amide

5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (2-acetyl-phenyl)-amide

2-aminoacetophenone

biotin

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