(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

Base Information

Chemical Name:(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate
CAS No.:1310744-93-4
Molecular Formula:C₂₉H₂₉N₃O₉S₂
Molecular Weight:627.696
Hs Code.:

Synonyms:(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

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Chemical Property of (R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

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Technology Process of (R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

There total 7 articles about (R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1243277-48-6
(R,Z)-dimethyl 2-(3-(((4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

: 1310744-93-4
(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

Guidance literature:: With triethylamine; at 0 - 20 ℃; for 24h;
DOI:10.1021/jm2002525

Reference yield:

: 4120-64-3
5-(4-nitrobenzylidene)-2-thioxothiazolidin-4-one

: 1310744-93-4
(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / ethanol / 2 h / Reflux

2.1: acetic acid / methanol / 1 h / 65 °C

2.2: 20 h / 20 °C / Inert atmosphere

3.1: triethylamine / 24 h / 0 - 20 °C

With tin(II) chloride dihdyrate; acetic acid; triethylamine; In methanol; ethanol;
DOI:10.1021/jm2002525

Reference yield:

: 1243277-30-6
(R)-dimethyl 2-(3-formylbenzamido)pentanedioate

: 1310744-93-4
(R,Z)-dimethyl 2-(3-((3-methoxy-3-oxo-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenyl)propanamido)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 1 h / 65 °C

1.2: 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / 24 h / 0 - 20 °C

With acetic acid; triethylamine; In methanol;
DOI:10.1021/jm2002525