(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Base Information

Chemical Name:(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene
CAS No.:879220-83-4
Molecular Formula:C₂₉H₄₁NO₄Si
Molecular Weight:495.734
Hs Code.:

Synonyms:(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

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Chemical Property of (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

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Technology Process of (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

There total 9 articles about (3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

: 879220-55-0
(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

: 814-68-6,25189-84-8
acryloyl chloride

: 879220-83-4
(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene; With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide;

acryloyl chloride; With triethylamine; In dichloromethane; cooling;
DOI:10.1021/jo060202z

Reference yield:

: [(1S,2S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-(2,4-dimethoxy-benzyl)-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 879220-83-4
(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/ol052781k DOI:10.1021/jo060390t

Reference yield:

: 878440-96-1
(3S,4S)-3-[(tert-butyl)dimethylsilyloxy]-4-[N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

: 879220-83-4
(3S,4S)-4-[N-acryloyl-N-(2,4-dimethoxybenzyl)amino]-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 90.6 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 20 °C

2: LiOH*H₂O; HSCH₂CO₂H / dimethylformamide / 20 °C

3: 76.2 mg / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With lithium hydroxide; mercaptoacetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Mitsunobu reaction;
DOI:10.1021/jo060390t