(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

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Chemical Name:(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene
CAS No.:879220-55-0
Molecular Formula:C₃₂H₄₂N₂O₇SSi
Molecular Weight:626.846
Hs Code.:

Synonyms:(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

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Chemical Property of (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

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Technology Process of (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

There total 5 articles about (3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

: 878440-96-1
(3S,4S)-3-[(tert-butyl)dimethylsilyloxy]-4-[N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 879220-55-0
(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃;
DOI:10.1021/ol052781k

Reference yield:

: N-((1S,2S)-1-Benzyl-2-hydroxy-but-3-enyl)-2-nitro-benzenesulfonamide

: 879220-55-0
(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 9.24 g / 2,6-lutidine / CH₂Cl₂ / 20 °C

2: 90.6 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 20 °C

With 2,6-dimethylpyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu reaction;
DOI:10.1021/jo060202z

Reference yield:

: (3S,4S)-4-Amino-5-phenyl-pent-1-en-3-ol; hydrochloride

: 879220-55-0
(3S,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-(2,4-dimethoxybenzyl)-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-collidine / CHCl₃ / 5 h / 20 °C

2: 9.24 g / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3: 90.6 percent / PPh₃; DEAD / tetrahydrofuran; toluene / 0 - 20 °C

With 2,6-dimethylpyridine; 2,4,6-trimethyl-pyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; chloroform; toluene;
DOI:10.1021/ol052781k