6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

Base Information

Chemical Name:6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one
CAS No.:310882-33-8
Molecular Formula:C₂₀H₂₅F₂N₃O₂
Molecular Weight:377.434
Hs Code.:

Synonyms:6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

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Chemical Property of 6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

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Technology Process of 6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

There total 19 articles about 6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.3%

: 41253-21-8
sodium triazole

: 310882-36-1
(2R-trans)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxohexyl)-2-[[(4-methylphenyl)sulfonyloxy]methyl]tetrahydrofuran

: 310882-33-8
6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at 100 ℃; for 44h;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: (2R-trans)-2-(2,4-difluorophenyl)-4-(5-methyl-4-oxo-2-hexenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

: 310882-33-8
6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;
DOI:10.1016/S0968-0896(00)00177-2

Reference yield:

: 58009-93-1
3-methyl-2-oxo-butylphosphonic acid dimethyl ester

: 310882-33-8
6-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-yl]-2-methyl-hexan-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5,4,0]undecen-7-ene; LiCl / acetonitrile / 3 h / 20 °C

2: 266 mg / H₂ / Pd/C / ethanol / 20 °C

With 1,8-diazabicyclo[5.4.0]-undecen-7-ene; hydrogen; lithium chloride; palladium on activated charcoal; In ethanol; acetonitrile; 1: Horner-Wadsworth-Emmons reaction / 2: Catalytic hydrogenation;
DOI:10.1016/S0968-0896(00)00177-2