methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate

Base Information

• Chemical Name: methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate
• CAS No.: 1452809-05-0
• Molecular Formula: C₂₇H₃₄N₂O₂
• Molecular Weight: 418.579
• Mol file: 1452809-05-0.mol

Synonyms:methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate

Chemical Property of methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate

There total 1 articles about methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 2-(bromomethyl)propenoate (4224-69-5) + 4-allyl-N,1-dibenzylpiperidin-4-amine (336108-92-0) → methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate (1452809-05-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.021

Reference yield: 82.0%

methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate (1452809-05-0) → methyl 1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxylate (1452809-06-1)

Guidance literature:

With dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II); In toluene; at 80 ℃; for 32h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.021

Reference yield:

methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate (1452809-05-0) → 1,9-dibenzyl-N-methyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxamide (1452809-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II) / toluene / 32 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

2.3: 15 h / 20 °C / Inert atmosphere

With dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II); lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;

DOI:10.1016/j.bmc.2013.07.021

upstream raw materials:

methyl 2-(bromomethyl)propenoate

4-allyl-N,1-dibenzylpiperidin-4-amine

Downstream raw materials:

methyl 1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxylate

1,9-dibenzyl-N-methyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxamide

1,9-dibenzyl-N,N-dimethyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxamide

(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone