(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

Base Information

Chemical Name:(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone
CAS No.:1452809-12-9
Molecular Formula:C₂₈H₃₅N₃O₂
Molecular Weight:445.605
Hs Code.:

Synonyms:(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

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Chemical Property of (1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

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Technology Process of (1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

There total 3 articles about (1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 110-91-8,99108-56-2
morpholine

: 1452809-06-1
methyl 1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxylate

: 1452809-12-9
(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

Guidance literature:: methyl 1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-ene-3-carboxylate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

morpholine; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: 1452809-05-0
methyl 2-(((4-allyl-1-benzylpiperidin-4-yl)(benzyl)amino)methyl) acrylate

: 1452809-12-9
(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II) / toluene / 32 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

2.3: 15 h / 20 °C / Inert atmosphere

With dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II); lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: 336108-92-0
4-allyl-N,1-dibenzylpiperidin-4-amine

: 1452809-12-9
(1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-3-yl)(morpholino) methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 18 h / 20 °C / Inert atmosphere

2.1: dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II) / toluene / 32 h / 80 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

3.3: 15 h / 20 °C / Inert atmosphere

With dichloro[1,3-bis(2-methylphenyl)-2-imidazolidinylidene](2-isopropoxyphenyl-methylene) ruthenium(II); potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.07.021