Technology Process of C12H14O3
There total 3 articles about C12H14O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-iodo-2-(dimethoxymethyl)benzene;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
at 25 ℃;
for 0.25h;
Inert atmosphere;
propargyl alcohol;
at 60 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ol1029047
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 25 °C / Inert atmosphere
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0.25 h / 25 °C / Inert atmosphere
2.2: 12 h / 60 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; triethylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/ol1029047
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: silica supported perchloric acid / 5 h / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: -78 - 25 °C / Inert atmosphere
3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0.25 h / 25 °C / Inert atmosphere
3.2: 12 h / 60 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; silica supported perchloric acid; triethylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/ol1029047
