5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Base Information

Chemical Name:5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide
CAS No.:1335234-01-9
Molecular Formula:C₁₃H₁₄ClN₃O
Molecular Weight:263.727
Hs Code.:

Synonyms:5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

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Technology Process of 5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

There total 4 articles about 5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 72881-70-0,56105-33-0
4-chlorostyryl cyclopropyl ketone

: 563-41-7
semicarbazide hydrochloride

: 1335234-01-9
5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: With sodium hydroxide; In ethanol; water; for 8h; Reflux;
DOI:10.1007/s12272-012-0606-9

Reference yield: 77.0%

: 72881-70-0
1-cyclopropyl-3-(p-chlorophenyl)prop-2-en-1-one

: 563-41-7
semicarbazide hydrochloride

: 1335234-01-9
5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: With acetic acid; In 1,4-dioxane; for 4h; Reflux;
DOI:10.3390/molecules16097736

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1335234-01-9
5-(4-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 5.5 h / Cooling

2: acetic acid / 1,4-dioxane / 4 h / Reflux

With acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; water; 1: Claisen-Schmidt condensation;
DOI:10.3390/molecules16097736