(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Base Information

Chemical Name:(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone
CAS No.:103246-53-3
Molecular Formula:C₂₄H₃₇BrO₆SSi
Molecular Weight:561.61
Hs Code.:

Synonyms:(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Suppliers and Price of (2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

There total 14 articles about (2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-hydroxymethyl-3-methoxy-4-methyl-cyclohexanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 103246-53-3
(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Guidance literature:: With imd.; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98918-4

Reference yield:

: 599-70-2
ethyl phenyl sulfone

: 103246-53-3
(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 14 steps

1: n-BuLi

2: 73 percent / n-BuLi

3: 98 percent / NaH

4: 96 percent / HCl / H₂O; methanol

5: 88 percent / pyridine

6: 89 percent / P₂O₅

7: 96 percent / EtMgBr / diethyl ether

8: 95 percent / PCC

9: 70 percent / NH₂OH_.HCl / various solvent(s)

10: 37 percent / NaOCl / triethylamine

11: 91 percent / HCl / methanol

12: 73 percent / NaH

13: 67 percent / Ti₃⁺ / methanol; H₂O

14: 80 percent / imd. / dimethylformamide

With pyridine; hydrogenchloride; sodium hypochlorite; n-butyllithium; ethylmagnesium bromide; hydroxylamine hydrochloride; phosphorus pentoxide; titanium(III); sodium hydride; pyridinium chlorochromate; In methanol; diethyl ether; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98918-4

Reference yield:

: (R)-4-Benzenesulfonyl-3-methoxy-4-methyl-hept-6-ene-1,2-diol

: 103246-53-3
(2S,3R,4R,6R)-4-Benzenesulfonyl-2-(2-bromo-allyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-4-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 10 steps

1: 88 percent / pyridine

2: 89 percent / P₂O₅

3: 96 percent / EtMgBr / diethyl ether

4: 95 percent / PCC

5: 70 percent / NH₂OH_.HCl / various solvent(s)

6: 37 percent / NaOCl / triethylamine

7: 91 percent / HCl / methanol

8: 73 percent / NaH

9: 67 percent / Ti₃⁺ / methanol; H₂O

10: 80 percent / imd. / dimethylformamide

With pyridine; hydrogenchloride; sodium hypochlorite; ethylmagnesium bromide; hydroxylamine hydrochloride; phosphorus pentoxide; titanium(III); sodium hydride; pyridinium chlorochromate; In methanol; diethyl ether; water; triethylamine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98918-4