1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

Base Information

Chemical Name:1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole
CAS No.:124751-02-6
Molecular Formula:C₂₈H₂₈ClN₃O₄S
Molecular Weight:538.067
Hs Code.:

Synonyms:1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

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Chemical Property of 1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

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Technology Process of 1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

There total 12 articles about 1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-10-2
benzenesulfonamide

: 1-[(2'-(benzenesulfomamidocarbonyl)biphenyl-4-yl)methyl]-2-butyl-4-chloro-5-hydroxymethylimidazole

: 124779-26-6
2-butyl-4-chloro-1-<<2'-<<(N,N-diphenylcarbamoyl)oxy>carbonyl>biphenyl-4-yl>methyl>-5-(hydroxymethyl)imidazole

: 124751-02-6
1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

Guidance literature:: With hydrogenchloride; In N-methyl-acetamide; methanol;

Reference yield:

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

: 124751-02-6
1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.00 N aq. NaOH / methanol / 0.75 h / 25 °C

2: 1.) sodium hydride / 1.) DMF, 25 deg C, 1 h, 2.) DMF, 25 deg C, 16 h

With sodium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 124751-02-6
1-<<2'-(benzenesulfonamidocarbonyl)biphenyl-4-yl>methyl>-2-butyl-4-chloro-5-(hydroxymethyl)imidazole

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

7: 1.00 N aq. NaOH / methanol / 0.75 h / 25 °C

8: 1.) sodium hydride / 1.) DMF, 25 deg C, 1 h, 2.) DMF, 25 deg C, 16 h

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium methylate; sodium hydride; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031