4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

Base Information

Chemical Name:4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid
CAS No.:114798-27-5
Molecular Formula:C22H23 Cl N2 O3
Molecular Weight:398.889
Hs Code.:
DSSTox Substance ID:DTXSID60150853
Nikkaji Number:J424.198C
Wikidata:Q83017108
ChEMBL ID:CHEMBL274447
Mol file:114798-27-5.mol

Synonyms:4'-((2-butyl-4-chloro-5--(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid;4'-IMI;EXP 7711;EXP-7711;EXP7711

Suppliers and Price of 4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

Chemical Property:

Boiling Point:602.8°Cat760mmHg
Flash Point:318.3°C
Density:1.25g/cm³
XLogP3:4.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:398.1397203
Heavy Atom Count:28
Complexity:498

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C(=O)O)CO)Cl

Technology Process of 4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid

There total 11 articles about 4'-((2-Butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 114772-43-9
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

Guidance literature:: With sodium hydroxide; In ethanol; for 14h; Heating;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium methylate; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

With sodium hydroxide; N-Bromosuccinimide; sodium methylate; copper; dibenzoyl peroxide; In tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031