N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

Base Information

Chemical Name:N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole
CAS No.:109908-79-4
Molecular Formula:C₂₂H₂₃NO₆S
Molecular Weight:429.494
Hs Code.:

Synonyms:N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

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Chemical Property of N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

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Technology Process of N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

There total 3 articles about N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 109908-78-3
3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

: 98-59-9
p-toluenesulfonyl chloride

: 109908-79-4
N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

Guidance literature:: With potassium carbonate; In butanone; for 3h; Heating;
DOI:10.1021/jm00394a020

Reference yield:

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 109908-79-4
N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeMgBr / 1.) THF, RT, 30 min, 2.) THF, from 0 deg C to RT, 45 min

2: 90 percent / BF₃*Et₂O / 0.42 h / Heating

3: 54 percent / K₂CO₃ / butan-2-one / 3 h / Heating

With boron trifluoride diethyl etherate; methylmagnesium bromide; potassium carbonate; In butanone;
DOI:10.1021/jm00394a020

Reference yield:

: 109908-92-1
4-(5-Methoxy-2-methyl-1H-indol-3-yl)-4-oxo-butyric acid

: 109908-79-4
N-(p-tolylsulfonyl)-3-(3'-carbomethoxypropanoyl)-5-methoxy-2-methylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / BF₃*Et₂O / 0.42 h / Heating

2: 54 percent / K₂CO₃ / butan-2-one / 3 h / Heating

With boron trifluoride diethyl etherate; potassium carbonate; In butanone;
DOI:10.1021/jm00394a020