N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Base Information

Chemical Name:N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide
CAS No.:1264366-95-1
Molecular Formula:C₂₅H₂₄N₂O₅
Molecular Weight:432.476
Hs Code.:

Synonyms:N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

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Chemical Property of N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

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Technology Process of N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

There total 9 articles about N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1264366-85-9
N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

: 1264366-95-1
N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 23h;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1264366-71-3
C₃₂H₃₂N₂O₆

: 1264366-95-1
N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077

Reference yield:

: 191097-27-5
methanesulfonic acid 3-benzyloxybenzyl ester

: 1264366-95-1
N-[(3-hydroxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium azide / N,N-dimethyl-formamide / 17 h / 50 °C / Inert atmosphere

2: water; triphenylphosphine / tetrahydrofuran / 6 h / 65 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

4: triethylamine; trichlorophosphate / dichloromethane / 4 h / -30 °C / Inert atmosphere

5: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

6: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

7: palladium 10% on activated carbon; hydrogen / ethanol / 23 h / 20 °C

With dmap; sodium azide; palladium 10% on activated carbon; water; hydrogen; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 5: Ugi condensation / 6: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077