N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Base Information

Chemical Name:N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide
CAS No.:1264366-85-9
Molecular Formula:C₃₂H₃₀N₂O₅
Molecular Weight:522.601
Hs Code.:

Synonyms:N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

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Chemical Property of N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

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Technology Process of N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

There total 9 articles about N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1264366-71-3
C₃₂H₃₂N₂O₆

: 1264366-85-9
N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201001077

Reference yield:

: 191097-27-5
methanesulfonic acid 3-benzyloxybenzyl ester

: 1264366-85-9
N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 17 h / 50 °C / Inert atmosphere

2: water; triphenylphosphine / tetrahydrofuran / 6 h / 65 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

4: triethylamine; trichlorophosphate / dichloromethane / 4 h / -30 °C / Inert atmosphere

5: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

6: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

With dmap; sodium azide; water; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 5: Ugi condensation / 6: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1700-30-7
(3-(benzyloxy)phenyl)methanol

: 1264366-85-9
N-[(3-benzyloxyphenyl)methyl]-2-(4-methoxyphenyl)-2-{6-methyl-3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 4.5 h / -30 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 17 h / 50 °C / Inert atmosphere

3: water; triphenylphosphine / tetrahydrofuran / 6 h / 65 °C

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 20 °C / Inert atmosphere

5: triethylamine; trichlorophosphate / dichloromethane / 4 h / -30 °C / Inert atmosphere

6: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

7: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

With dmap; sodium azide; water; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 6: Ugi condensation / 7: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077