(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane

Base Information

• Chemical Name: (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane
• CAS No.: 884381-88-8
• Molecular Formula: C₁₇H₂₁ClN₂O₂S
• Molecular Weight: 352.885
• Mol file: 884381-88-8.mol

Synonyms:(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane

Chemical Property of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane

There total 3 articles about (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(p-toluenesulfonyloxy)methyl]-1,3-dioxalane (143327-63-3) + sodium thiomethoxide (5188-07-8) → (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane (884381-88-8)

Guidance literature:

With caesium carbonate; In acetone; for 6h; Reflux;

DOI:10.1016/j.bmc.2009.01.078

Reference yield:

4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone (82362-50-3) → (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane (884381-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

2: caesium carbonate / acetone / 6 h / Heating / reflux

With caesium carbonate; toluene-4-sulfonic acid; In acetone; toluene; butan-1-ol;

Reference yield:

1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole (67085-11-4) → (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(methylthio)methyl]-1,3-dioxolane (884381-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; dimethyl sulfoxide; triethylamine

2: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

3: caesium carbonate / acetone / 6 h / Heating / reflux

With oxalyl dichloride; caesium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In acetone; toluene; butan-1-ol; 1: Swern Oxidation;

upstream raw materials:

(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(p-toluenesulfonyloxy)methyl]-1,3-dioxalane

sodium thiomethoxide

1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone