6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

Base Information

Chemical Name:6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one
CAS No.:1393726-78-7
Molecular Formula:C₁₅H₁₂F₂N₂O₂
Molecular Weight:290.269
Hs Code.:

Synonyms:6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

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Chemical Property of 6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

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Technology Process of 6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

There total 4 articles about 6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1393726-73-2
6-benzyl-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione

: 1393726-78-7
6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1016/j.tet.2012.05.122

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 1393726-78-7
6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / dimethyl sulfoxide / 15 h / 50 °C

2.1: sulfuric acid / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 0 - 60 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 0 °C

With dimethylsulfide borane complex; sulfuric acid; copper; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.05.122

Reference yield:

: 1393726-71-0
ethyl (3-cyanopyridin-2-yl)difluoroacetate

: 1393726-78-7
6-benzyl-8,8-difluoro-7,8-dihydro-7-hydroxy-1,6-naphthyridine-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

2.2: 0 - 60 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / 0 °C

With dimethylsulfide borane complex; sulfuric acid; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.05.122