Technology Process of 1-azido-4-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)butane
There total 4 articles about 1-azido-4-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)butane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2',3',4',6'-tetra-O-benzyl-α-D-glucopyranosyl)butan-1-ol;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
diphenyl phosphoryl azide;
In
tetrahydrofuran;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium periodate / osmium(VIII) oxide / butan-1-ol; water; tert-butyl alcohol; acetone / 1.5 h / 20 °C
2.1: toluene / 2 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 2 h / 0 °C
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
4.2: 0 - 20 °C
With
sodium periodate; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine;
osmium(VIII) oxide;
In
tetrahydrofuran; water; acetone; toluene; tert-butyl alcohol; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene / 2 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / 0 °C
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C
With
lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran; toluene;
