lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

Base Information

Chemical Name:lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate
CAS No.:1620583-17-6
Molecular Formula:C₂₈H₂₅Cl₂FN₃O₃*Li
Molecular Weight:548.37
Hs Code.:

Synonyms:lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

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Chemical Property of lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

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Technology Process of lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

There total 9 articles about lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1448870-40-3
5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid methyl ester

: 1620583-17-6
lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 60 ℃; for 21h;

Reference yield:

: 2106-04-9
3-chloro-2-fluoroaniline

: 1620583-17-6
lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 20 °C

2: lithium hydroxide monohydrate; water / 1,4-dioxane / 21 h / 60 °C

With lithium hydroxide monohydrate; water; In 1,4-dioxane; dichloromethane;

Reference yield:

: 5-[(4-chloro-2-methyl-phenyl)hydroxy-methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylic acid methyl ester

: 1620583-17-6
lithium 5-[(3-chloro-2-fluoro-phenylamino)-(4-chloro-2-methyl-phenyl)methyl]-1-isopropyl-2-(2-methoxy-phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / 20 °C

2: dichloromethane / 16 h / 20 °C

3: lithium hydroxide monohydrate; water / 1,4-dioxane / 21 h / 60 °C

With lithium hydroxide monohydrate; water; triethylamine; In 1,4-dioxane; dichloromethane;