4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

Base Information

Chemical Name:4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol
CAS No.:135454-77-2
Molecular Formula:C₂₄H₂₄FNO
Molecular Weight:361.459
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

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Chemical Property of 4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

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Technology Process of 4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

There total 5 articles about 4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137586-44-8
4-(4-Fluoro-phenyl)-2-isopropyl-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-carboxylic acid ethyl ester

: 135454-77-2
4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Yield given; Ambient temperature;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135454-77-2
4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With piperidine; lithium aluminium tetrahydride; copper diacetate; ammonium acetate; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-43-7
β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

: 135454-77-2
4-(4-fluorophenyl)-6,7-dihydro-2-(1-methylethyl)-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; In tetrahydrofuran; acetic acid;
DOI:10.1021/jm00113a019