(R)-4-p-tolylpentanoic acid

Base Information

• Chemical Name: (R)-4-p-tolylpentanoic acid
• CAS No.: 196402-67-2
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• Mol file: 196402-67-2.mol

Synonyms:(R)-4-p-tolylpentanoic acid

Chemical Property of (R)-4-p-tolylpentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-p-tolylpentanoic acid

There total 18 articles about (R)-4-p-tolylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-4-p-tolylpent-3-enoic acid (1086246-37-8) → (R)-4-p-tolylpentanoic acid (196402-67-2)

Guidance literature:

(E)-4-p-tolylpent-3-enoic acid; With (Sa,S)-[(C8H12)Ir(P(3,5-(methyl)2C6H3)2C8H7CC8H7C3NOH3(α-naphthylmethyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine; In methanol; at 65 ℃; for 12h; under 2280.15 Torr; Autoclave;

With sodium hydroxide; In methanol; water;

With hydrogenchloride; In water; pH=1; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.201107802

Reference yield: 84.0%

(R)-(-)-α-curcumene (4176-17-4,644-30-4,3649-81-8,4176-06-1) → (R)-4-p-tolylpentanoic acid (196402-67-2)

Guidance literature:

With chromium(VI) oxide; osmium(VIII) oxide; sulfuric acid; Ambient temperature;

DOI:10.1016/S0957-4166(97)00284-X

Reference yield: 78.0%

diethyl 2-(2-(p-tolyl)propyl)malonate (1413723-41-7) → (R)-4-p-tolylpentanoic acid (196402-67-2)

Guidance literature:

diethyl 2-(2-(p-tolyl)propyl)malonate; With water; potassium hydroxide; In ethanol; at 20 ℃;

With hydrogenchloride; In ethanol; water;

DOI:10.1016/j.tetasy.2012.09.008

upstream raw materials:

(R)-(-)-α-curcumene

(E)-4-p-tolylpent-3-enoic acid

2-(4-methylphenyl)propanal

1-methyl-4-isopropenylbenzene

Downstream raw materials:

(R)-methyl 4-p-tolylpentanoate

(R)-(-)-α-curcumene

(-)-(R)-4-(p-tolyl)pentanal