(R)-methyl 4-p-tolylpentanoate

Base Information

• Chemical Name: (R)-methyl 4-p-tolylpentanoate
• CAS No.: 1374459-89-8
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 1374459-89-8.mol

Synonyms:(R)-methyl 4-p-tolylpentanoate

Chemical Property of (R)-methyl 4-p-tolylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 4-p-tolylpentanoate

There total 9 articles about (R)-methyl 4-p-tolylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(R)-4-p-tolylpentanoic acid (196402-67-2) + methyl iodide (74-88-4) → (R)-methyl 4-p-tolylpentanoate (1374459-89-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1002/anie.201107802

Reference yield:

C15H20O4 (1612882-47-9) → (R)-methyl 4-p-tolylpentanoate (1374459-89-8) + methyl (4S)-(4-methylphenyl)pentanoate (72493-22-2)

Guidance literature:

With lithium chloride; In water; dimethyl sulfoxide; at 160 ℃; for 13h; Overall yield = 80 %;

DOI:10.1002/adsc.201300250

Reference yield:

(E)-4-p-tolylpent-3-enoic acid (1086246-37-8) → (R)-methyl 4-p-tolylpentanoate (1374459-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (Sa,S)-[(C8H12)Ir(P(3,5-(methyl)2C6H3)2C8H7CC8H7C3NOH3(α-naphthylmethyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine / methanol / 12 h / 65 °C / 2280.15 Torr / Autoclave

1.3: pH 1

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With (Sa,S)-[(C8H12)Ir(P(3,5-(methyl)2C6H3)2C8H7CC8H7C3NOH3(α-naphthylmethyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/anie.201107802

upstream raw materials:

(E)-4-p-tolylpent-3-enoic acid

2-(4-methylphenyl)propanal

(R)-4-p-tolylpentanoic acid

methyl iodide

Downstream raw materials:

(-)-(R)-4-(p-tolyl)pentanal

(R)-(-)-α-curcumene