(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

Base Information

Chemical Name:(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol
CAS No.:144402-41-5
Molecular Formula:C₃₂H₃₈O₄S₂
Molecular Weight:550.783
Hs Code.:

Synonyms:(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

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Chemical Property of (2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

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Technology Process of (2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

There total 1 articles about (2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 81380-10-1
(2S,3S)-4-benzyloxy-1,2-epoxy-3-methylbutane

: 144402-27-7
2-<(2S)-2,3-O-(diphenylmethylidene)-2,3-dihydroxypropyl>-1,3-dithiane

: 144402-41-5
(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) -40 deg C, 2 h; 2.) -30 deg C, 40 h;
DOI:10.1016/0040-4020(95)00214-S

Reference yield: 99.0%

: 144402-41-5
(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

: 144402-28-8
(2S,6R,7S)-8-benzyloxy-1,2-O-diphenylmethylidene-7-methyloctan-4-one-1,2,6-triol

Guidance literature:: With mercury(II) perchlorate; calcium carbonate; In tetrahydrofuran; water; for 0.5h; Ambient temperature;
DOI:10.1016/0040-4020(95)00214-S

Reference yield:

: 144402-41-5
(2R,3S)-4-Benzyloxy-1-[2-((S)-2,2-diphenyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-3-methyl-butan-2-ol

: C₃₂H₅₀O₉S₂Si

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / MeI, CaCO₃, H₂O / acetonitrile / 16 h

2: 95 percent / NaBH₄, Et₂BOMe / tetrahydrofuran; methanol / 3 h / -78 °C

3: 90 percent / PPTS / CH₂Cl₂ / 0.33 h

4: 81 percent / H₂ / Pd(OH)2/C / ethyl acetate / 0.5 h

5: 99 percent / imidazole / dimethylformamide / 3.5 h

6: 81 percent / Li, NH₃ (liq.) / tetrahydrofuran; propan-2-ol / 0.25 h / -70 °C

7: Py / 2.5 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; diethyl methoxy borane; ammonia; water; hydrogen; pyridinium p-toluenesulfonate; lithium; calcium carbonate; methyl iodide; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.3987/COM-92-6041