(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

Base Information

Chemical Name:(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether
CAS No.:909907-87-5
Molecular Formula:C₁₇H₂₃BrN₂O₂
Molecular Weight:367.286
Hs Code.:

Synonyms:(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

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Chemical Property of (3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

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Technology Process of (3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

There total 1 articles about (3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 914399-92-1
(6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: 589-15-1
1-bromomethyl-4-bromobenzene

: 909907-87-5
(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

Guidance literature:: (6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1h;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2006.06.019

Reference yield: 97.0%

: 909907-87-5
(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: 321901-73-9
(R)-α-methyl-4-bromophenylalanine methyl ester

Guidance literature:: With trifluoroacetic acid; In water; acetonitrile; at 20 ℃; for 10h;
DOI:10.1016/j.tetasy.2006.06.019

Reference yield:

: 909907-87-5
(3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: (R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-1,5-dimethylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / trifluoroacetic acid / acetonitrile; H₂O / 10 h / 20 °C

2.1: dimethylsulfoxide / 1 h / 20 °C

2.2: 89 percent / sodium carbonate / dimethylsulfoxide / 12 h / 120 °C

3.1: 100 percent / lithium bis(trimethylsilyl)amide / dimethylformamide; hexane / 0 - 20 °C

With trifluoroacetic acid; lithium hexamethyldisilazane; In hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tetasy.2006.06.019