321901-73-9

Upstream product

• 909907-87-5 (3R,6S)-3-(4-bromobenzyl)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether 
• 23632-41-9 (E)-3-(4-bromophenyl)-2-methylacrylaldehyde 
• 186497-72-3 2-methyl-3-(4-bromophenyl)propanol 
• 246529-83-9 rac-3-(4-bromophenyl)-2-methylpropanal 
• 1122-91-4 4-bromo-benzaldehyde 
• 848149-43-9 (R)-3-(4-bromophenyl)-2-(1,2-bis(benzyloxycarbonyl)hydrazinyl)-2-methylpropanoic acid 
• 848149-45-1 (R)-methyl 3-(4-bromophenyl)-2-(1,2-bis(benzyloxycarbonyl)hydrazinyl)-2-methylpropanoate 
• 848149-47-3 (R)-methyl 3-(4-bromophenyl)-2-methyl-2-(1-benzyloxycarbonyl-2-(2,2,2-trifluoroacetyl)hydrazinyl)propanoate 
• 848149-41-7 (R)-3-(4-bromophenyl)-2-(1,2-bis(benzyloxycarbonyl)hydrazinyl)-2-methylpropanal 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 848149-49-5 (R)-methyl 2-(benzyloxycarbonylamino)-3-(4-bromophenyl)-2-methylpropanoate 

Downstream Products

• 321901-72-8 C₁₂H₁₂BrNO₃ 
• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 

Relevant academic research and scientific papers

Improved Schoellkopf construction of quaternary α-amino acids: efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377

The Schoellkopf methodology for the asymmetric synthesis of α-amino acids which was previously not applicable to the construction of α,α-dialkylated (quaternary) α-amino acids, has been rendered practical for this purpose and applied in a highly efficient

Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter

(Chemical Equation Presented) A catalytic route for enantioselective total synthesis of cell adhesion inhibitor BIRT-377 is described. The quaternary stereocenter was constructed through L-proline-derived, tetrazole-catalyzed direct asymmetric α-amination