N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Base Information

Chemical Name:N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester
CAS No.:201210-78-8
Molecular Formula:C₁₅H₁₄FN₃O₅
Molecular Weight:335.292
Hs Code.:

Synonyms:N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

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Chemical Property of N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

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Technology Process of N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

There total 2 articles about N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201210-70-0
succinic acid benzyl ester (5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl ester

: 201210-78-8
N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / 1,4-cyclohexadiene / Pd/C / acetic acid / 1 h / Ambient temperature

2: 43 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

3: 59 percent / dimethylformamide / 16 h

With cyclohexa-1,4-diene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo971076p

Reference yield:

: 201210-72-2
succinic acid mono[(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)methyl] ester

: 201210-78-8
N-Phenyl-succinamic acid 5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / EDCI*HCl / dimethylformamide / 2 h / Ambient temperature

2: 59 percent / dimethylformamide / 16 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jo971076p