4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate

Base Information

• Chemical Name: 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate
• CAS No.: 1346128-66-2
• Molecular Formula: C₂₁H₁₇N₃O₆
• Molecular Weight: 407.382
• Mol file: 1346128-66-2.mol

Synonyms:4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate

Chemical Property of 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate

There total 4 articles about 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-nitropyridine-4-carbonyl azide (852102-17-1) + 4-(hydroxymethyl)phenyl 2-phenylacetate (192999-56-7) → 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate (1346128-66-2)

Guidance literature:

In benzene; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2011.09.019

Reference yield:

4-formylphenyl 2-phenylacetate → 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate (1346128-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: benzene / Reflux; Inert atmosphere

With sodium tetrahydroborate; In tetrahydrofuran; benzene;

DOI:10.1016/j.bmc.2011.09.019

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-((((3-nitropyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate (1346128-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: benzene / Reflux; Inert atmosphere

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1016/j.bmc.2011.09.019

upstream raw materials:

3-nitropyridine-4-carbonyl azide

4-(hydroxymethyl)phenyl 2-phenylacetate

4-hydroxy-benzaldehyde

phenylacetyl chloride

Downstream raw materials:

4-((((3-aminopyridin-4-yl)carbamoyl)oxy)methyl)phenyl 2-phenylacetate