2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole
CAS No.:719274-47-2
Molecular Formula:C₂₄H₂₉F₃N₂O₃
Molecular Weight:450.501
Hs Code.:

Synonyms:2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

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Chemical Property of 2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

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Technology Process of 2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

There total 4 articles about 2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719274-46-1
4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]octane-1-carboxylic acid

: 344-95-6
2-(trifluoromethyl)benzohydrazide

: 719274-47-2
2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In dichloromethane; for 2h;

Reference yield:

: 719274-44-9
methyl 4-[(1E)-3-(2-methyl-1,3-dioxolan-2-yl)prop-1-enyl]bicyclo[2.2.2]octane-1-carboxylate

: 719274-47-2
2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

2: potassium hydroxide; water / methanol / Heating / reflux

3: 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine / dichloromethane / 2 h

With potassium hydroxide; water; hydrogen; 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;

Reference yield:

: 94994-25-9
4-carbomethoxybicyclo<2.2.2>octane-1-carboxaldehyde

: 719274-47-2
2-{4-[3-(2-methyl-1,3-dioxolan-2-yl)propyl]bicyclo[2.2.2]oct-1-yl}-5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h

3.1: potassium hydroxide; water / methanol / Heating / reflux

4.1: 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine / dichloromethane / 2 h

With potassium hydroxide; water; hydrogen; potassium hexamethylsilazane; 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;