1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

Base Information

Chemical Name:1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol
CAS No.:385844-34-8
Molecular Formula:C₂₇H₃₃FN₂O₂
Molecular Weight:436.57
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

There total 1 articles about 1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(4-fluoro-phenyl)-2-{4-[4-(2-methoxy-naphthalen-1-yl)-butyl]-piperazin-1-yl}-ethanone

: 385844-34-8
1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In ethanol; water; at 50 ℃; for 1h;
DOI:10.1016/j.bmc.2006.12.039

Reference yield:

: 385844-34-8
1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

: 88569-66-8,137186-14-2
1-methylethylpiperazine dihydrochloride

: 124-63-0
methanesulfonyl chloride

: 385844-35-9,788814-36-8,913691-73-3
1-[2-(4-Fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine

Guidance literature:: With triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 385844-34-8
1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}ethanol

: C₃₅H₄₉FN₄O

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / cooling

2: triethylamine / CH₂Cl₂ / 3 h / 20 °C

With triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2006.12.039