(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Chemical Name:(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate
CAS No.:1567220-75-0
Molecular Formula:C₄₁H₅₁ClN₄O₅
Molecular Weight:715.333
Hs Code.:

(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Synonyms:(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Chemical Property of (2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

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Technology Process of (2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

There total 5 articles about (2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1567220-45-4
(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-bromo-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

: 1567220-71-6
2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1567220-75-0
(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide;

Reference yield:

: 958646-70-3
(2-chloro-6-hydroxyphenyl) boronic acid

: 1567220-75-0
(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 105 °C / Microwave irradiation

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / N,N-dimethyl-formamide

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 260558-15-4
4-bromo-2-iodo-1-methylbenzene

: 1567220-75-0
(2S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-chloro-6-methyl-6’-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 105 °C / Microwave irradiation

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / N,N-dimethyl-formamide

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;