3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione

Base Information

• Chemical Name: 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione
• CAS No.: 374081-65-9
• Molecular Formula: C₃₃H₃₀N₄O₄S₂
• Molecular Weight: 610.758
• Mol file: 374081-65-9.mol

Synonyms:3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione

Chemical Property of 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione

There total 22 articles about 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-one (374081-64-8) → 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thione (374081-65-9)

Guidance literature:

With tetraphosphorus decasulfide; In pyridine; for 24h; Heating;

DOI:10.1021/jo0255476

Reference yield:

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol (374081-64-8) → 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thiol (374081-65-9)

Guidance literature:

With tetraphosphorus decasulfide; In pyridine;

DOI:10.1021/ol0165443

Reference yield:

benzyl bromide (100-39-0) → 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene-7-thiol (374081-65-9)

Guidance literature:

Multi-step reaction with 8 steps

1: NaH; Bu₄NI

2: EtMgBr

3: NH₂OH*HCl; NaHCO₃

4: 90 percent / Ac₂O

5: 50 percent / K₂CO₃

6: 90 percent / NaOEt / ethanol

7: 82 percent / Ac₂O

8: P₂S₅ / pyridine

With tetraphosphorus decasulfide; ethylmagnesium bromide; hydroxylamine hydrochloride; sodium ethanolate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In pyridine; ethanol;

DOI:10.1021/ol0165443

upstream raw materials:

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

benzyl bromide

4,5-dibromo-1-(β-D-ribofuranosyl)imidazole

4,5-dibromo-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole

Downstream raw materials:

6-[3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-imidazol-4-yl]-pyrimidin-4-ylamine

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ylamine

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-7-methylsulfanyl-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]indene