(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

Base Information

Chemical Name:(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol
CAS No.:1312018-77-1
Molecular Formula:C₂₁H₁₇FN₂O₃S₂
Molecular Weight:428.508
Hs Code.:

Synonyms:(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

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Chemical Property of (1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

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Technology Process of (1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

There total 1 articles about (1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

: 1015608-79-3
1-(benzenesulfonyl)-5-fluoropyrrolo[2,3-b]pyridine

: 3446-89-7
4-(Methylthio)benzaldehyde

: 1312018-77-1
(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

Guidance literature:: 1-(benzenesulfonyl)-5-fluoropyrrolo[2,3-b]pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.583333h;

4-(Methylthio)benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield: 90.0%

: 1312018-77-1
(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

: 1312018-78-2
(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanone

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;

Reference yield:

: 1312018-77-1
(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-phenyl)-methanol

: 1312016-79-7
2-[2-cyclobutyl-1-(4-methanesulfonyl-phenyl)-ethyl]-5-fluoro-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: Dess-Martin periodane / dichloromethane / 1 h / 25 °C

2: tetrahydrofuran / 1 h / 0 °C

3: sodium periodate / water; methanol / 8 h / 20 °C

4: potassium permanganate / water; methanol / 2 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 8 h / 50 °C / 2585.81 Torr

With potassium permanganate; sodium periodate; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;